How do I make FTP, or a cloud service, the source? How do I backup files from an FTP server or cloud service?

When creating a new profile simply select FTP (or the appropriate cloud service) as the Source.

What if I want to change an existing profile?

Modify it, select Easy tab from the list on the right panel, go to the Type settings page, and select the second option (to copy FTP/Cloud to Destination, the exact text may be different depending on the labels you have given to your locations).