How can I create a shortcut to run SyncBackFree/SE/Pro with a specific profile?

Simply click on the profile in the main window, hold the left mouse button down, "drag" the profile to the desktop, and release the left mouse button.

Bear in mind that by default a shortcut (like any other command-line trigger) will run the profile (etc.) in Unattended mode.

This also works for Groups. You can also edit the command-line in the shortcut to incorporate numerous command-line parameters. See the Technical Reference > Command Line Parameters section of the help file or Help > Search > 'command-line' (without the quotes) for more command-line background, syntax, etcetera. Note however that the majority of such parameters are not supported in SyncBackFree.